Aim of present study is to prepare and evaluate dual properties of binding and colon targeting efficiency of Abelmoschus esculentus gum tablets containing ibuprofen as a model drug by direct compression technique. Prepared tablets were then evaluated for various formulation characteristics such as physical appearance and surface texture, thickness, hardness, weight variation, % friability, drug content analysis, In-vitro drug release and drug release studies in pH-6.8 phosphate buffer saline with and without 4% rat caecal contents. Characteristics of gum as well as tablets were found acceptable as per standard specifications. Results of drug release studies for formulations (F4 & F5) were found more i.e. 76.71% & 68.51%, when studied in dissolution medium with 4% rat caecal contents in comparison to control medium i.e. 31.45% & 27.24%. It may be due to enzymatic degradation of gum matrix in presence of rat caecal content by colonic bacterial enzymes (such as Bacteroides, Bifidobacterium, Eubacterium, Peptococcus, Lactobacillus, Clostridium etc.). Hence, based on present study, we can conclude that, Abelmoschus esculentus gum can be used as a potential carrier for successful targeting of drug to colon specific drug delivery system in the form of direct compressed tablets.
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